Mary Regina Boland

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Journal Publications

1.  MR Boland, P Parhi, R Miotto, R Carroll, U Iqbal, P-A Nguyen, M Schuemie, SC You, D Smith, S Mooney, P Ryan, Y-C Li, RW Park, J Denny, JT Dudley, G Hripcsak, P Gentine, NP Tatonetti. Uncovering Exposures Responsible for Birth Season – Disease Effects: A Global Study. J Am Med Inform Assoc. 2017; In press.

2. MR Boland, P Parhi, P Gentine, NP Tatonetti. Climate Classification is an Important Factor in Assessing Quality-of-Care Across Hospitals. Scientific Reports. 2017; 7: 4948. [Link]

3. MR Boland, K Karczewski, NP Tatonetti. Ten Simple Rules to Enable Multi-site Collaborations through Data Sharing. PLOS Computational Biology. 2017; 13 (1), e1005278[Link]

4. MR Boland, NP Tatonetti. Investigation of 7-DeHydroCholesterol Reductase Pathway to Elucidate Off-Target Prenatal Effects of Pharamceuticals: A Systematic Review. The Pharmacogenomics Journal. 2016; 16(5): 411–429.  [Link]

5. L Li*, MR Boland*, R Miotto*, NP Tatonetti, J Dudley. Replicating Cardiovascular Condition-Birth Month Associations. Scientific Reports.  2016; 6: 33166. *Joint Contribution First-Author  [Link]

6. K Roberts, MR Boland, L Pruinelli, JD Cruz, A Berry, M Georgsson, R Hazen, RF Sarmiento, U Backonja, K-H Yu, Y Jiang, PF Brennan. Biomedical informatics advancing the national health agenda: The AMIA 2015 Year-in-Review in clinical & consumer informatics. J Am Med Inform Assoc. 2016; 24 (e1), e185-e190. [Link]

7. K Gayvert, E Dardenne, C Cheung, MR Boland, T Lorberbaum, J Wanjala, Y Chen, M Rubin, NP Tatonetti, D Rickman, O Elemento. A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors. Cell Reports. 2016; 15 (11), 2348-2356.  [Link]

8. N Nissim, MR Boland, NP Tatonetti, Y Elovici, G Hripcsak, Y Shahar, R Moskovitch. Improving Condition Severity Classification with an Efficient Active Learning Based Framework. Journal of biomedical informatics. 2016; 61, 44-54[Link]

9. MR Boland*, A Jacunski*, T Lorberbaum*, JD Romano, R Moskovitch, NP Tatonetti.  Systems Biology Approaches for Identifying Adverse Drug Reactions and Elucidating Their Underlying Biological Mechanisms. WIREs Systems Biology and Medicine, 2016; 8 (2), 104-122. * Equal contribution first-author. [Link]

10.  A Oellrich*, N Collier*, T Groza*, D Rebholz-Schuhmann*, N Shah*, O Bodenreider, MR Boland, I Georgiev, H Liu, K Livingston, A Luna, A-M Mallon, P Manda, PN Robinson, G Rustici, M Simon, L Wang, R Winnenburg, M Dumontier. The digital revolution in phenotyping. Briefings in Bioinformatics2015; 17 (5), 819-830. * Equal contribution first-author. [Link]

11.  MR Boland,  Z Shahn, D Madigan, G Hripcsak, NP Tatonetti. Birth Month Affects Lifetime Disease Risk: A Phenome-Wide Method.  Journal of the American Medical Informatics Association, 2015; 22(5):1042-1053. [Link]

12. BA Kidd, A Wroblewska, MR Boland, J Agudo, M Merad, NP Tatonetti, BD Brown, JT Dudley. Mapping the effects of drugs on the immune system. Nature Biotechnology. 2016; 34:47-54. [Link] 

13.  MR Boland, NP Tatonetti, G Hripcsak. Development and Validation of a Classification Approach for Extracting Severity Automatically from Electronic Health Records. Journal of Biomedical Semantics, 2015; 6(14). Highly Accessed. [Link]

14.  T Hao, A Rusanov, MR Boland, C Weng. Clustering clinical trials with similar eligibility features.  Journal of Biomedical Informatics, 2014;  52 : 112-120. [Link]

15. MR Boland, A Rusanov, Y So, Y Li, C Lopez-Jimenez, L Busacca, RC Steinman, S Bakken, JT Bigger, C Weng. 
From Expert-Derived User Needs to User-Perceived Usability and Usefulness: A Two-Phase Mixed-Methods Evaluation Framework, Journal of Biomedical Informatics, 2014; 52 : 141-150.[Link]

16. MR Boland, G Hripcsak, Y Shen, WK Chung, C Weng. Defining a Comprehensive Verotype Using Electronic Health Records for Personalized Medicine. Journal of the American Medical Informatics Association, 2013; 20(e2)e232-8. [Link] [Short News Summary]

17.  C Weng, Y Li, S Berhe, MR Boland, J Gao, GW Hruby, RC Steinman, C Lopez-Jimenez, L Busacca, G Hripcsak, S Bakken, JT Bigger.
An Integrated Model for Patient Care and Clinical Trials (IMPACT) to Support Clinical Research Visit Scheduling Workflow for Future Learning Health Systems. Journal of Biomedical Informatics, 2013; 46 (4): 642-652. [Link]

18. MR Boland, R Miotto, J Gao, C Weng. Feasibility of feature-based indexing, clustering, and search of clinical trials: A case study of breast cancer trials from ClinicalTrials.gov. Methods of Information in Medicine, 2013; 52(5): 382-394. [Link] [Bioportal: Feature Hierarchy]
19. MR Boland, G Hripcsak, DJ Albers, Y Wei, AB Wilcox, J Wei, J Li, S Lin, M Breene, R Myers, J Zimmerman, PN Papapanou, C Weng, 
Discovering Medical Conditions Associated with Periodontitis Using Linked Electronic Health Records. Journal of Clinical Periodontology, 2013; 40(5): 474-82. [Link] [News Article]  Top Paper in the "Practice of Informatics", 2013 AMIA Annual Year in Review. [Link]
20. MR Boland, S Trembowlski, S Bakken, C Weng, An Initial Log Analysis of Usage Patterns on a Research Networking System. Clinical and Translational Science, 2012; 5(4): 340-347. [Link]
21. C Weng, X Wu, Z Luo, MR Boland, D Theodoratos, SB Johnson, EliXR: An Approach to Eligibility Criteria Extraction and Representation. Journal of the American Medical Informatics Association. 2011; 18 Suppl 1:i116-i124. (Distinguished Paper of the 2011 AMIA Translational Summit Meeting). [Link] 


Conference/Workshop Proceedings

22. MR Boland, NP Tatonetti. In Search of ‘Birth Month Genes’: Using Existing Data Repositories to Locate Genes Underlying Birth Month-Disease Relationships. AMIA Summits on Translational Science Proceedings; 2016. (In Press). Finalist for Distinguished Student Paper Award 2016 AMIA Translational Summit. [Link]

23. MR Boland, NP Tatonetti. Are All Vaccines Created Equal? Using Electronic Health Records to Discover Vaccines Associated With Clinician-Coded Adverse Events. AMIA Summits on Translational Science Proceedings 2015, San Francisco, CA, USA. 2015; 196-200. (1st Place Winner Student Paper Competition of the AMIA Translational Bioinformatics Meeting). [Link]

24. N Nissim, MR Boland, R Moskovitch, NP Tatonetti, Y Elovici, Y Shahar, G Hripcsak. Active Learning Framework for Efficient
Condition Severity Classification. Artificial Intelligence in Medicine. 2015; 13-24. Mario Stefanelli Best Student Paper Award

25. V Agarwal, P LePendu, T Podchiyska, R Barber, MR Boland, G Hripcsak, N Shah. Using narratives as a source to automatically learn phenotype models. Data Mining for Medicine and Healthcare (DMMI) Proc. 2014; Washington DC, USA 2014. 

26. N Nissim, MR Boland, R Moskovitch, N Tatonetti, Y Elovici, Y Shahar, G Hripcsak. CAESAR-ALE: An Active Learning Enhancement for Conditions Severity Classification. ACM KDD on Workshop on Connected Health at Big Data Era; NYC, USA, 2014. 

27. MR Boland, NP Tatonetti, G Hripcsak. CAESAR: a Classification Approach for Extracting Severity Automatically from Electronic Health Records. Intelligent Systems for Molecular Biology Phenotype Day. 2014; Boston, MA. 

28. C Weng, MR Boland,  Y So, A Rusanov, C Lopez-Jiminez, R Steinman, L Busacca, S Bakken, JT Bigger. Using Software to Elicit User Needs for Clinical Research Visit Scheduling. AMIA Summits on Translational Science Proceedings. 2014; San Francisco, CA In Press. [Link]

29. CL Gordon, S Pouch, LG Cowell, MR Boland, HL Platt, A Goldfain, C Weng. Design and Evaluation of a Bacterial Clinical Infectious Diseases Ontology. Proceedings of the AMIA Annual Symposium 2013; 502-511.  (Finalist Student Paper Competition of the 2013 AMIA Annual Meeting) [Link]

30. MR Boland*, R Miotto*, C Weng. A Method for Probing Disease Relatedness Using Common Clinical Eligibility Criteria. MEDINFO 2013, Copenhagen, Denmark. Stud Health Technol Inform. 2013; 192:481-5. * Equal contribution first-author. [Link]

31. G Hruby, MR Boland, JJ Cimino, J Gao, AB Wilcox, J Hirschberg, C Weng, Characterization of the Biomedical Query Mediation Process. AMIA Summits on Translational Science Proceedings, San Francisco, CA, 2013; 89-93. (Finalist Distinguished Paper of the 2013 AMIA Translational Summit Meeting)  [Link]

32. MR Boland, SW Tu, S Carini, I Sim, C Weng, EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria. AMIA Summits on Translational Science Proceedings, San Francisco, CA, 2012; 71-80. [Link]


Scientific Reports

33. YJ Lee, MR Boland, S Bakken, C Weng. Ontology Alignment for Linking a Homegrown Research Networking System to VIVO: Findings and Implications for Standards Development. 2013.

34. MR Boland, S Trembowelski, DC Dine, RC Steinman, S Bakken, C Weng. How Are Research Networking Systems Used and by Whom? A Case Study Using Google Analytics. 2013.



Peer-Reviewed Conference/Workshop/Symposium Abstracts:

1. *MR Boland, NP Tatonetti. Assessing the Mutational Spectrum of 7-DeHydroCholesterol Reductase and the Toxicological Effects of Pharmacological Inhibition During the Prenatal Period; (Abstract / Prenatal, Perinatal and Reproductive Genetics #3260T). Presented at the 66th Annual Meeting of The American Society of Human Genetics, October 20, 2016, Vancouver, Canada.

2. *MR Boland, L Li, R Miotto, J Dudley, NP Tatonetti. Cardiovascular Disease Risk And Birth Month? Discovering and Replicating Novel Birth Month Associations. Data Science Day at Columbia University, New York, NY, USA (poster), April 3, 2016

3. *MR Boland, NP Tatonetti. In Search of ‘Birth Month Genes’: Using Existing Data Repositories to Locate Genes Underlying Birth Month-Disease Relationships. AMIA Summits on Translational Science Proceedings 2016, San Francisco, CA, USA.

4. F Polubriaginof, A Perotte, MR Boland, D Vawdrey. Quality of Race and Ethnicity Data in Electronic Health Records.

AMIA Summits on Translational Science Proceedings 2016 , San Francisco, CA, USA (podium).

5. *MR Boland, G Hripcsak, P Ryan, NP Tatonetti. A Climate-Wide Journey to Explore Mechanisms Underlying Birth Month-Disease Risk Associations: A Call for Collaboration. Observational Heatlh Data Sciences and Informatics Symposium 2015, Washington DC, USA (poster).

6. *MR Boland, Z Shahn, D Madigan, G Hripcsak, NP Tatonetti. Using Electronic Health Records to Uncover Disease-Birth Month Dependencies. National Library of Medicine Informatics Trainee Conference 2015, National Library of Medicine, Bethesda, MD, USA (focus session).

7. *MR Boland, Z Shahn, D Madigan, G Hripcsak, NP Tatonetti. Using Electronic Health Records to Uncover Disease-Birth Month Dependencies. 2015 Symposium on Advances in Genomics, Epidemiology and Statistics (SAGES), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (poster). Received Travel Award

8. N Nissim, MR Boland, R Moskovitch, NP Tatonetti, Y Elovici, Y Shahar, G Hripcsak. Active Learning Framework for Efficient Condition Severity Classification. Conference on Artificial Intelligence in Medicine (AIME). 2015; Pavia, Italy.

9. *MR Boland, NP Tatonetti. Are All Vaccines Created Equal? Using Electronic Health Records to Discover Vaccines Associated With Clinician-Coded Adverse Events. AMIA Summits on Translational Science Proceedings 2015, San Francisco, CA, USA. (oral presentation).

10. *MR Boland, Z Shahn, D Madigan, G Hripcsak, NP Tatonetti. Using Electronic Health Records to Uncover Disease-Birth Month Dependencies. AMIA Summits on Translational Science Proceedings 2015, San Francisco, CA, USA (poster). 

11. B Kidd, A Wroblewska, MR Boland, J Agudo, M Merad, NP Tatonetti, B Brown, J Dudley. Systematic integrative analysis of immune pharmacology. AMIA Summits on Translational Science Proceedings 2015, San Francisco, CA, USA (poster).

12. V Agarwal, P LePendu, T Podchiyska, R Barber, MR Boland, G Hripcsak, N Shah. Using narratives as a source to automatically learn phenotype models. Data Mining for Medicine and Healthcare (DMMI) Proc. 2014, Washington DC, USA.

13. N Nissim, MR Boland, R Moskovitch, NP Tatonetti, Y Elovici, YShahar, G Hripcsak. CAESAR-ALE: An Active Learning Enhancement for Conditions Severity Classification. SIGKDD 2014, New York, NY, USA.

14. *MR Boland, NP Tatonetti, G Hripcsak. CAESAR: a Classification Approach for Extracting Severity Automatically from Electronic Health Records. Intelligent Systems for Molecular Biology Phenotype Day. 2014; Boston, MA. [Link]

15. MR Boland, R Miotto, C Weng. A method for probing disease relatedness using common clinical eligibility criteria. MEDINFO 2013, Copenhagen, Denmark.

16. YJ Lee, MR Boland, S Bakken, C Weng. Ontology Alignment for Linking a Homegrown Research Networking System to VIVO: Findings and Implications for Standards Development. AMIA Summits on Translational Science Proceedings 2013 p.99 (poster)

17. *MR Boland, S Trembowelski, D Dine, RC Steinman, S Bakken, C Weng. Using Google Analytics to Elucidate Research Networking System Usage. Clinical and Translational Science Award Annual Meeting 2012 (poster). 

18. YJ Lee, MR Boland, S Bakken, C Weng. Aligning One CTSA’s Research Networking System to VIVO. Clinical and Translational Science Award Annual Meeting 2012 (podium). [Link]

19. *MR Boland, G Hripcsak, DJ Albers, Y Wei, A Wilcox, J Wei, M Breene, J Zimmerman, C Weng. Linked Records Reveal Associations between Oral and Overall Health. Clinical and Translational Science Award Annual Meeting 2012 (poster).

20. *MR Boland, SB Johnson, S Trembowelski, DC Dine, RC Steinman, S Bakken, C Weng. An Initial Log-based Usage Analysis of Research Networking Systems. AMIA Summits on Translational Science Proceedings, San Francisco, CA, 2012; 148. (Podium) [File]

21. *MR Boland, S Tu, S Carini, I Sim, C Weng. EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria. AMIA Summits on Translational Science Proceedings 2012: 71-80 (oral presentation). [Link]

22. *MR Boland, ML Sierk. Annotation of Putatively Conserved Non-Coding Regions in Branchiostoma Floridae. National Conference for Undergraduate Research 2010, Missoula MT (poster). [Link] [File]

23. *MR Boland, R Parker. Optimizing Cancer Chemotherapy Administration: Effect of Model Structure on Treatment Cost and Effect. Undergraduate Research in Tissue Engineering (Pittsburgh-Based Affiliate Research Institutes) 2009, Pittsburgh PA (poster No 3). [Link] [File]

24. *MR Boland, M Raab, M Sangimino. Data Design & Flow for RAE: An interactive web- based biomedical informatics system for pediatric orthopedic patients. Duquesne University Summer Research Symposium 2008, Pittsburgh PA (poster No 84). [Link] [File]

*Mary Regina Boland Gave Oral Presentation of Research